Class I Major Histocompatibility Complex-Restricted Cytotoxic T Lymphocytes Are Not Necessary For Heterotypic Immunity To Influenza
Identifieur interne : 001E09 ( Main/Exploration ); précédent : 001E08; suivant : 001E10Class I Major Histocompatibility Complex-Restricted Cytotoxic T Lymphocytes Are Not Necessary For Heterotypic Immunity To Influenza
Auteurs : Bradley S. Bender [États-Unis] ; Wade E. Bell ; Scott Taylor ; Parker A. SmallSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1994.
Abstract
Mice transgenic for p2-micrQglobulin deletion (β2 M-/-) were immunized intranasally with either a recombinant vaccinia virus that expressed both nucleoprotein and interleukin-2 or by infection with H3N2 influenza virus; 3–4 weeks later they were challenged with H1N1 influenza virus. The immunized β2 M-/- mice had increased survival and enhanced clearance of virus relative to nonimmune controls. This protection correlated with the development of class II major histocompatibility complex-restricted pulmonary cytotoxic T lymphocyte activity and nasal IgA anti-nucleoprotein antibody. Heterotypic immunity can therefore be generated by a mechanism that does not involve class I major histocompatibility complex-restricted T cells.
Url:
DOI: 10.1093/infdis/170.5.1195
Affiliations:
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<front><div type="abstract">Mice transgenic for p2-micrQglobulin deletion (β2 M-/-) were immunized intranasally with either a recombinant vaccinia virus that expressed both nucleoprotein and interleukin-2 or by infection with H3N2 influenza virus; 3–4 weeks later they were challenged with H1N1 influenza virus. The immunized β2 M-/- mice had increased survival and enhanced clearance of virus relative to nonimmune controls. This protection correlated with the development of class II major histocompatibility complex-restricted pulmonary cytotoxic T lymphocyte activity and nasal IgA anti-nucleoprotein antibody. Heterotypic immunity can therefore be generated by a mechanism that does not involve class I major histocompatibility complex-restricted T cells.</div>
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